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Dosage Guidelines for U-48800

General Considerations

  1. Start Low, Go Slow: Begin with the lowest possible dose to assess individual tolerance and response.
  2. Precise Measurement: Use a milligram scale to ensure accurate dosing. Due to the potency, even small variations in dose can have significant effects.
  3. Tolerance: If you have a tolerance to opioids, this will influence the effective dose.

Suggested Dosages

  • Threshold Dose: 0.5-1 mg
  • Light Dose: 1-3 mg
  • Common Dose: 3-6 mg
  • Strong Dose: 6-10 mg
  • Heavy Dose: 10+ mg (not recommended due to high risk of adverse effects)

Administration Routes

  • Oral: Often considered the safest and easiest method. Start with the lowest dose to gauge effects.
  • Nasal: Provides faster onset and higher bioavailability compared to oral, but also increases the risk of adverse effects.
  • Intravenous: Highly potent and immediate effects. This method carries the highest risk and should only be used by those with experience in opioid administration and in a controlled environment.

Tips for Safe Use

  1. Set and Setting: Use in a safe and controlled environment, ideally with someone who can assist in case of adverse reactions.
  2. Avoid Mixing: Do not combine U-48800 with other depressants like alcohol, benzodiazepines, or other opioids, as this can greatly increase the risk of respiratory depression.
  3. Hydration and Nutrition: Ensure you are well-hydrated and have eaten, as opioids can affect your metabolism and hydration levels.
  4. Stay Informed: Keep up to date with any new research or user reports on U-48800 to stay informed about potential risks and best practices.

Recognizing Overdose and What to Do

  • Signs of Overdose: Extreme drowsiness, slow or difficult breathing, blue lips or fingertips, loss of consciousness.
  • Emergency Response: Call emergency services immediately. If available, administer naloxone (Narcan), an opioid antagonist that can temporarily reverse the effects of an overdose.


U-48800 is a potent synthetic opioid that requires careful dosing and respect for its powerful effects. By starting with a low dose, using precise measurement tools, and adhering to harm reduction practices, you can mitigate the risks associated with its use. Always prioritize safety and seek professional help if needed. buy u-48800 powder USA, buy u-48800 powder USA.

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Additional Information


1kg, 5g, 10g, 25g, 50g, 500g

1 review for U-48800

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