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UR-144 is a synthetic cannabinoid that was developed by scientists at the Hebrew University of Jerusalem. The compound is thought to be potent and may have effects similar to marijuana, though it has much less research on its effects. UR144’s potency is significantly less than those of JWH-018 or SR-18 and the side effects may include hallucinations, loss of coordination, nausea, decreased heart rate, and seizures.
UR-144, also referred to as (1-(5-fluoropentyl)-1H-indazole – 3,4-dihydro – 2H – 3C – indolizin – 2-one) is a synthetic cannabinoid. The chemical designation of this substance is 4-(1-adamantoyl) indole, 5-(4-bromo butyramide) pentanoic acid. It is the C3 homologue of TM-38841 (naphthalen 1 yl indole 1 carboxamide).
Uses & Effects.
UR-144 is a potent and selective agonist for the CB2 cannabinoid receptor. The CB1/CB2 receptor system is widely distributed in the central nervous and immune systems and in numerous peripheral organs and tissues. In cannabinoid receptor knockout mice, the cannabinoid receptors have been completely absent. CB2 receptors have been detected on activated T lymphocytes, macrophages, microglial cells, B lymphocytes, mast cells and bronchial epithelial cells. The CB2 receptor may play a role in the immunomodulatory effects of cannabinoids.
U-144 is an orally active inhibitor of the liver enzyme 11ß-hydroxysteroid dehydrogenase type 1, the enzyme that converts the inactive form of cortisol (11-ketocorticoid) to its active form (cortisol). This effect leads to a reduced metabolism of corticosteroids, including cortisol and dehydroepiandrosterone (DHEA).
UR-144 For Sale | SFCC-Chemicals.
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