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Aromasin™ (exemestane) is a Selective Estrogen Receptor Modulator (SERM) indicated for use in combination with anastrozole or with tamoxifen in the treatment of postmenopausal women with estrogen receptor positive, human epidermal growth factor receptor 2 negatives (HER2-) advanced breast cancer, who have received at least 2 prior chemotherapy regimens for their metastatic disease.
Exemestane was approved by the FDA in 2013 and is used to treat breast cancer in postmenopausal women and advanced prostate cancer in men. It belongs to a class of drugs called aromatase inhibitors. Given as soon as one to two months after menopause and even after the surgical removal of breasts, it can be used for many years before losing its effectiveness.
Uses & Effects.
Aromasin is an orally bioavailable small molecule with a novel mechanism of action, a selective aromatase inhibitor that has demonstrated single agent activity in the treatment of advanced breast cancer.
For men who have low or no testosterone, Exemestane is approved to treat breast cancer that has spread to other parts of the body. The combination of Exemestane and an estrogen hormone medicine (adjuvant therapy) may be used to treat postmenopausal women with ER-positive early-stage breast cancer.
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